Associations between neuropsychiatric symptoms and incident Alzheimer's dementia in men versus women.

ABSTRACT:

Objective

To examine whether associations between individual neuropsychiatric symptoms (NPS) and incident Alzheimer's dementia (AD) differ in men versus women.

Methods

Data were acquired from the National Alzheimer's Coordinating Center (NACC) Uniform Data Set. Two sets of older (≥ 60 years) participants were formed: one of cognitively unimpaired (CU) individuals, and one of participants with mild cognitive impairment (MCI). NPS were assessed using the Neuropsychiatric Inventory Questionnaire. Cox proportional hazards models examined associations between individual NPS and AD incidence separately for each participant set. These models featured individual NPS, sex, NPS by sex interactions as well as a number of covariates.

Results

The analysis involved 9,854 CU individ

SUBMITTER: Liampas I 

PROVIDER: S-EPMC10025238 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature