Optical coherence tomography reflects clinically relevant gray matter damage in patients with multiple sclerosis.

ABSTRACT:

Background

Retinal degeneration leading to optical coherence tomography (OCT) changes is frequent in patients with multiple sclerosis (PwMS).

Objective

To investigate associations among OCT changes, MRI measurements of global and regional brain volume loss, and physical and cognitive impairment in PwMS.

Methods

95 PwMS and 52 healthy controls underwent OCT and MRI examinations. Mean peripapillary retinal nerve fiber layer (pRNFL) thickness and ganglion cell/inner plexiform layer (GCIPL) volume were measured. In PwMS disability was quantified with the Expanded Disability Status Scale (EDSS) and Symbol Digit Modalities Test (SDMT). Associations between OCT, MRI, and clinical measures were investigated with multivariable regression models.

Results

In PwMS, pRNFL a

SUBMITTER: Cagol A 

PROVIDER: S-EPMC10025239 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature