Comprehensive Proteomics Analysis Identifies CD38-Mediated NAD⁺ Decline Orchestrating Renal Fibrosis in Pediatric Patients With Obstructive Nephropathy.

ABSTRACT: Obstructive nephropathy is one of the leading causes of kidney injury and renal fibrosis in pediatric patients. Although considerable advances have been made in understanding the pathophysiology of obstructive nephropathy, most of them were based on animal experiments and a comprehensive understanding of obstructive nephropathy in pediatric patients at the molecular level remains limited. Here, we performed a comparative proteomics analysis of obstructed kidneys from pediatric patients with ureteropelvic junction obstruction and healthy kidney tissues. Intriguingly, the proteomics revealed extensive metabolic reprogramming in kidneys from individuals with ureteropelvic junction obstruction. Moreover, we uncovered the dysregulation of NAD⁺ metabolism and NAD⁺-related m

SUBMITTER: Tao Y 

PROVIDER: S-EPMC10025283 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature