Maternal overnutrition is associated with altered synaptic input to lateral hypothalamic area.

ABSTRACT:

Objective

Maternal overnutrition is associated with adverse outcomes in offspring, including increased risk for obesity and diabetes. Here, we aim to test the effects of maternal obesity on lateral hypothalamic feeding circuit function and determine the relationship with body weight regulation.

Methods

Using a mouse model of maternal obesity, we assessed how perinatal overnutrition affected food intake and body weight regulation in adult offspring. We then used channelrhodopsin-assisted circuit mapping and electrophysiological recordings to assess the synaptic connectivity within an extended amygdala-lateral hypothalamic pathway.

Results

We show that maternal overnutrition during gestation and throughout lactation produces offspring that are heavier than controls prio

SUBMITTER: Shrivastava K 

PROVIDER: S-EPMC10025284 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature