Common properties of nuclear body protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.

ABSTRACT: The SP100 protein, together with PML, represents a major constituent of the PML-SP100 nuclear bodies (NBs). The function of these ubiquitous subnuclear structures, whose integrity is compromised in pathological situations such as acute promyelocytic leukemia (APL) or DNA virus infection, remains poorly understood. There is little evidence for the occurrence of actual physiological processes within NBs. The two NB proteins PML and SP100 are covalently modified by the ubiquitin-related SUMO-1 modifier, and recent work indicates that this modification is critical for the regulation of NB dynamics. In exploring the functional relationships between NBs and chromatin, we have shown previously that SP100 interacts with members of the HP1 family of nonhistone chromosomal proteins and that a varian

SUBMITTER: Seeler JS 

PROVIDER: S-EPMC100253 | biostudies-literature | 2001 May

REPOSITORIES: biostudies-literature