Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data.

ABSTRACT:

Objectives

Many observational studies evaluate the association between vitamin B12 and non-alcoholic fatty liver disease (NAFLD). However, the causality of this association remains uncertain, especially in European populations. We conducted a bidirectional Mendelian randomization study to explore the association between vitamin B12 and NAFLD.

Methods

Two-sample Mendelian randomization study was conducted. Summary statistics for vitamin B12 were acquired from a genome-wide association studies (GWAS) meta-analysis including 45,576 subjects. Summary-level data for NAFLD was obtained from a GWAS meta-analysis of 8,434 cases and 770,180 non-cases and another GWAS meta-analysis of 1,483 cases and 17,781 non-cases. Summary-level data for 4 enzymes including alkaline phosphatase (AL

SUBMITTER: Fu L 

PROVIDER: S-EPMC10025356 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature