The Foundational Data Initiative for Parkinson Disease: Enabling efficient translation from genetic maps to mechanism.

ABSTRACT: The Foundational Data Initiative for Parkinson Disease (FOUNDIN-PD) is an international collaboration producing fundamental resources for Parkinson disease (PD). FOUNDIN-PD generated a multi-layered molecular dataset in a cohort of induced pluripotent stem cell (iPSC) lines differentiated to dopaminergic (DA) neurons, a major affected cell type in PD. The lines were derived from the Parkinson's Progression Markers Initiative study, which included participants with PD carrying monogenic PD variants, variants with intermediate effects, and variants identified by genome-wide association studies and unaffected individuals. We generated genetic, epigenetic, regulatory, transcriptomic, and longitudinal cellular imaging data from iPSC-derived DA neurons to understand molecular relationships betwe

SUBMITTER: Bressan E 

PROVIDER: S-EPMC10025424 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature