HGTphyloDetect: facilitating the identification and phylogenetic analysis of horizontal gene transfer.

ABSTRACT:

Background

Horizontal gene transfer (HGT) is an important driver in genome evolution, gain-of-function, and metabolic adaptation to environmental niches. Genome-wide identification of putative HGT events has become increasingly practical, given the rapid growth of genomic data. However, existing HGT analysis toolboxes are not widely used, limited by their inability to perform phylogenetic reconstruction to explore potential donors, and the detection of HGT from both evolutionarily distant and closely related species.

Results

In this study, we have developed HGTphyloDetect, which is a versatile computational toolbox that combines high-throughput analysis with phylogenetic inference, to facilitate comprehensive investigation of HGT events. Two case studies with Saccharomyces c

SUBMITTER: Yuan L 

PROVIDER: S-EPMC10025432 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature