Maternal nano-titanium dioxide inhalation alters fetoplacental outcomes in a sexually dimorphic manner.

ABSTRACT: The placenta plays a critical role in nutrient-waste exchange between the maternal and fetal circulations, thus functioning as an interface that profoundly impacts fetal growth and development. The placenta has long been considered an asexual organ, but, due to its embryonic origin it shares the same sex as the fetus. Exposures to toxicant such as diesel exhaust, have been shown to result in sexually dimorphic outcomes like decreased placental mass in exposed females. Therefore, we hypothesize that maternal nano-TiO₂ inhalation exposure during gestation alters placental hemodynamics in a sexually dimorphic manner. Pregnant Sprague-Dawley rats were exposed from gestational day 10-19 to nano-TiO₂ aerosols (12.17 ± 1.69 mg/m³) or filtered air (sham-control). D

SUBMITTER: Griffith JA 

PROVIDER: S-EPMC10025460 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature