Niclosamide does not modulate airway epithelial function through blocking of the calcium activated chloride channel, TMEM16A.

ABSTRACT: Niclosamide and benzbromarone have been described as inhibitors of the calcium activated chloride channel, TMEM16A, and on this basis have been considered and tested as clinical candidates for the treatment of airway diseases. However, both compounds have previously demonstrated activity on a range of additional biological targets and it is unclear from the literature to what extent any activity on TMEM16A may contribute to efficacy in these models of airway disease. The aim of the present study was therefore to examine the pharmacology and selectivity of these clinical candidates together with a structurally unrelated TMEM16A blocker, Ani9, in a range of functional assays to better appreciate the putative role of TMEM16A in the regulation of both epithelial ion transport and the developme

SUBMITTER: Danahay H 

PROVIDER: S-EPMC10025480 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature