Prognostic and immunological characteristics of CDK1 in lung adenocarcinoma: A systematic analysis.

ABSTRACT:

Background

Cyclin-dependent kinases (CDKs) play a key role in cell proliferation in lung adenocarcinoma (LUAD). Comprehensive analysis of CDKs to elucidate their clinical significance and interactions with the tumor immune microenvironment is needed.

Methods

RNA expression, somatic mutation, copy number variation, and single-cell RNA sequencing data were downloaded from public datasets. First, we comprehensively evaluated the expression profile and prognostic characteristics of 26 CDKs in LUAD, and CDK1 was selected as a candidate for further analysis. Then, a systematic analysis was performed to explore the relationships of CDK1 with clinical characteristics and tumor immune microenvironment factors in LUAD.

Results

CDK1 was markedly upregulated at both the mRNA and

SUBMITTER: Du Q 

PROVIDER: S-EPMC10025485 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature