TRPC1 channel clustering during store-operated Ca²⁺ entry in keratinocytes.

ABSTRACT: Skin is the largest organ in the human body with ∼95% of its surface made up of keratinocytes. These cells maintain a healthy skin barrier through regulated differentiation driven by Ca²⁺-transcriptional coupling. Many important skin conditions arise from disruption of this process although not all stages are fully understood. We know that elevated extracellular Ca²⁺ at the skin surface is detected by keratinocyte Gα_q-coupled receptors that signal to empty endoplasmic reticulum Ca²⁺ stores. Orai channel store-operated Ca²⁺ entry (SOCE) and Ca²⁺ influx via "canonical" transient receptor potential (TRPC)-composed channels then activates transcription factors that drive differentiation. While STIM-mediated activation of

SUBMITTER: Manning D 

PROVIDER: S-EPMC10025536 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature