Pro-inflammatory and pro-resolving lipid mediators of inflammation in HIV: effect of aspirin intervention.

ABSTRACT:

Background

Persons with HIV (PWH) have an increased risk of cardiovascular disease (CVD) compared to HIV-seronegative individuals (SN). Inflammation contributes to this risk but the role of lipid mediators, with central roles in inflammation, in HIV infection remain to be established; further aspirin reduces CVD risk in the general population through production of some of these anti-inflammatory lipid mediators, but they have not been studied in PWH.

Methods

We evaluated the relationship between plasma lipid mediators (i.e. 50 lipid mediators including classic eicosanoids and specialized pro-resolving mediators (SPMs)) and HIV status; and the impact of aspirin in PWH on regulating these autacoids. Plasma samples were obtained from 110 PWH receiving antiretroviral therapy (AR

SUBMITTER: Dalli J 

PROVIDER: S-EPMC10025757 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature