Epigenome-wide association study of plasma lipids in West Africans: the RODAM study.

ABSTRACT:

Background

DNA-methylation has been associated with plasma lipid concentration in populations of diverse ethnic backgrounds, but epigenome-wide association studies (EWAS) in West-Africans are lacking. The aim of this study was to identify DNA-methylation loci associated with plasma lipids in Ghanaians.

Methods

We conducted an EWAS using Illumina 450k DNA-methylation array profiles of extracted DNA from 663 Ghanaian participants. Differentially methylated positions (DMPs) were examined for association with plasma total cholesterol (TC), LDL-cholesterol, HDL-cholesterol, and triglycerides concentrations using linear regression models adjusted for age, sex, body mass index, diabetes mellitus, and technical covariates. Findings were replicated in independent cohorts of different

SUBMITTER: van der Linden EL 

PROVIDER: S-EPMC10025759 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature