TIST: Transcriptome and Histopathological Image Integrative Analysis for Spatial Transcriptomics.

ABSTRACT: Sequencing-based spatial transcriptomics (ST) is an emerging technology to study in situ gene expression patterns at the whole-genome scale. Currently, ST data analysis is still complicated by high technical noises and low resolution. In addition to the transcriptomic data, matched histopathological images are usually generated for the same tissue sample along the ST experiment. The matched high-resolution histopathological images provide complementary cellular phenotypical information, providing an opportunity to mitigate the noises in ST data. We present a novel ST data analysis method called transcriptome and histopathological image integrative analysis for ST (TIST), which enables the identification of spatial clusters (SCs) and the enhancement of spatial gene expression patterns by in

SUBMITTER: Shan Y 

PROVIDER: S-EPMC10025771 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature