Pulmonary functional MRI: Detecting the structure-function pathologies that drive asthma symptoms and quality of life.

ABSTRACT: Pulmonary functional MRI (PfMRI) using inhaled hyperpolarized, radiation-free gases (such as ³ He and ¹²⁹ Xe) provides a way to directly visualize inhaled gas distribution and ventilation defects (or ventilation heterogeneity) in real time with high spatial (~mm³ ) resolution. Both gases enable quantitative measurement of terminal airway morphology, while ¹²⁹ Xe uniquely enables imaging the transfer of inhaled gas across the alveolar-capillary tissue barrier to the red blood cells. In patients with asthma, PfMRI abnormalities have been shown to reflect airway smooth muscle dysfunction, airway inflammation and remodelling, luminal occlusions and airway pruning. The method is rapid (8-15 s), cost-effective (~$300/scan) and very well tolerated in pa

SUBMITTER: Kooner HK 

PROVIDER: S-EPMC10025897 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature