Controllable DNA nanodevices regulated by logic gates for multi-stimulus recognition† † Electronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3ra00295k

ABSTRACT: DNA biosensors have attracted considerable attention due to their great potential in environmental monitoring and medical diagnosis. Despite the great achievements, the single function and uncontrollability of the sensors restrict their further application. Therefore, it is necessary to construct controllable nanodevices with both sensing and responding capabilities to external stimuli. Herein, we develop a strategy to engineer structure-switching biosensors which can respond to external stimuli while preserving the sensing capability. The engineered nanodevice consists of an actuation module and a sensing module. Initially, the sensing module is disabled by a blocker strand which acts as an allosteric switch. Once the stimuli-responsive actuation module displaces the blocker DNA, the sens

SUBMITTER: Hu Y 

PROVIDER: S-EPMC10025943 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature