White matter alterations and the conversion to psychosis: A combined diffusion tensor imaging and glutamate ¹H MRS study.

ABSTRACT:

Introduction

Widespread white matter abnormalities and alterations in glutamate levels have been reported in patients with schizophrenia. We hypothesized that alterations in white matter integrity and glutamate levels in individuals at clinical high risk (CHR) for psychosis are associated with the subsequent development of psychosis.

Methods

Participants included 33 antipsychotic naïve CHR (Female 7/Male 26, Age 19.55 (4.14) years) and 38 healthy controls (Female 10/Male 28, Age 20.92 (3.37) years). Whole brain diffusion tensor imaging for fractional anisotropy (FA) and right frontal white matter proton magnetic resonance spectroscopy for glutamate levels were acquired. CHR participants were clinically followed for 2 years to determine conversion to psychosis.

Results

SUBMITTER: Leon-Ortiz P 

PROVIDER: S-EPMC10025976 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature