Effects of drug and hazardous alcohol use on having a detectable HIV viral load: An adherence mediation analysis

ABSTRACT: Highlights • People living with HIV (PWH) with substance use or alcohol use often have detectable plasma HIV viral loads that are predictive of negative clinical outcomes.• Among PWH with substance or alcohol use, it is not known what proportion of the observed detectable HIV viremia is mediated through medication nonadherence.• Use of amphetamines, opioids, and multiple substances but not alcohol predicted having a detectable HIV viral load.• Up to 40% of the substance use effects were mediated by self-reported adherence.

Objectives

People living with HIV (PWH) with substance or alcohol use often have unsuppressed plasma HIV viral loads (pVL). The degree to which substance and alcohol use effects on HIV viral suppression are mediated through medication nonadherence is incompletel

SUBMITTER: Cachay E 

PROVIDER: S-EPMC10025983 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature