A rapidly evolving landscape: immune checkpoint inhibitors in pretreated metastatic endometrial cancer.

ABSTRACT:

Background and objectives

Endometrial cancer is a common malignancy and recurrences can be fatal. Although platinum-pretreated endometrial tumors are commonly treated with anthracyclines and taxanes, there is no current standard of care. Both immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs) have been extensively assessed in this setting, including tumors selected for DNA mismatch repair (MMR)/microsatellite instability (MSI) and programmed death-ligand 1 expression status. This review will provide evidence-based guidance on use of ICIs alone or in combination with TKIs in patients with pretreated advanced, persistent, or recurrent metastatic endometrial cancer.

Data sources and methods

Randomized phase II-III trials in unselected populations pretreat

SUBMITTER: Tinker AV 

PROVIDER: S-EPMC10026109 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature