A systematic review on the available treatment modalities for Bacillus Calmette-Guerin-unresponsive carcinoma in situ and tumors in patients who are ineligible for or decline radical cystectomy.

ABSTRACT:

Introduction

Globally, urothelial bladder carcinoma is a disease which carries a poor prognosis. There are various treatment modalities for urothelial bladder carcinoma with intravesical Bacillus Calmette-Guérin immunotherapy being the most efficacious intravesical therapy and the treatment of choice for patients with carcinoma in situ. A number of chemotherapeutic drugs are also available for the management of Ta/T1 tumors such as mitomycin C and epirubicin. However, relapse and progression is quite common. The optimal management of patients with Bacillus Calmette-Guérin-unresponsive disease remains to be a challenge. The purpose of this study was to conduct a systematic review on the treatment modalities available for the management of Bacillus Calmette-Guérin-unresponsive carcin

SUBMITTER: Syed S 

PROVIDER: S-EPMC10026116 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature