A systematic review of therapeutic strategies in gastroenteropancreatic grade 3 neuroendocrine tumors.

ABSTRACT:

Background

Gastroenteropancreatic (GEP) neuroendocrine neoplasms with Ki-67 > 20% were subdivided in the most recent 2019 World Health Organization histopathological classification into grade 3 (G3) neuroendocrine tumors (NETs), described as well-differentiated tumors, and neuroendocrine carcinomas, which are described as poorly differentiated tumors. This classification met the demand noted for different prognoses between these subgroups, prompting the need for treatment recommendations for well-differentiated G3 tumors.

Methods

We systematically searched medical literature databases and oncology conferences for studies on G3 GEP NET to describe epidemiology, diagnosis, molecular features, and treatments used. We excluded studies that did not discriminate G3 NET data. Data

SUBMITTER: Donadio MD 

PROVIDER: S-EPMC10026121 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature