Behavioural and dopaminergic signatures of resilience.

ABSTRACT: Chronic stress can have lasting adverse consequences in some individuals, yet others are resilient to the same stressor^1,2. Susceptible and resilient individuals exhibit differences in the intrinsic properties of mesolimbic dopamine (DA) neurons after the stressful experience is over^3-8. However, the causal links between DA, behaviour during stress and individual differences in resilience are unknown. Here we recorded behaviour in mice simultaneously with DA neuron activity in projections to the nucleus accumbens (NAc) (which signals reward^9-12) and the tail striatum (TS) (which signals threat^13-16) during social defeat. Supervised and unsupervised behavioural quantification revealed that during stress, resilient and susceptible mice use differen

SUBMITTER: Willmore L 

PROVIDER: S-EPMC10026178 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature