Seven bacterial response-related genes are biomarkers for colon cancer.

ABSTRACT:

Background

Colon cancer (CC) is a common tumor that causes significant harm to human health. Bacteria play a vital role in cancer biology, particularly the biology of CC. Genes related to bacterial response were seldom used to construct prognosis models. We constructed a bacterial response-related risk model based on three Molecular Signatures Database gene sets to explore new markers for predicting CC prognosis.

Methods

The Cancer Genome Atlas (TCGA) colon adenocarcinoma samples were used as the training set, and Gene Expression Omnibus (GEO) databases were used as the test set. Differentially expressed bacterial response-related genes were identified for prognostic gene selection. Univariate Cox regression analysis, least absolute shrinkage and selection operator-penalized

SUBMITTER: Xiong Z 

PROVIDER: S-EPMC10026208 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature