Monitoring small airway dysfunction in connective tissue disease-related interstitial lung disease: a retrospective and prospective study.

ABSTRACT:

Background

Small airway dysfunction (SAD), a hallmark of early lung function abnormality, is a major component of several chronic respiratory disorders. The role of SAD in patients with connective tissue disease-related interstitial lung disease (CTD-ILD) has not been explored.

Methods

We conducted a two-parts (retrospective and prospective) study to collect pulmonary function tests from CTD-ILD patients. SAD was defined as at least two of the three measures (MMEF, FEF 50%, and FEF 75%) must be 65% of predicted values. Spearman correlation coefficient was used to evaluate association between SAD and other pulmonary function parameters. Mixed effects regression modeling analysis was used to assess response to treatment.

Results

CTD-ILD patients with SAD and without SAD

SUBMITTER: Xu L 

PROVIDER: S-EPMC10026226 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature