In Silico Analysis of a Candidate Multi-epitope Peptide Vaccine Against Human Brucellosis.

ABSTRACT: Brucellosis is one of the neglected endemic zoonoses in the world. Vaccination appears to be a promising health strategy to prevent it. This study used advanced computational techniques to develop a potent multi-epitope vaccine for human brucellosis. Seven epitopes from four main brucella species that infect humans were selected. They had significant potential to induce cellular and humoral responses. They showed high antigenic ability without the allergenic characteristic. In order to improve its immunogenicity, suitable adjuvants were also added to the structure of the vaccine. The physicochemical and immunological properties of the vaccine were evaluated. Then its two and three-dimensional structure was predicted. The vaccine was docked with toll-like receptor4 to assess its ability to

SUBMITTER: Yazdani Z 

PROVIDER: S-EPMC10026239 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature