Uncovering heterogeneous cognitive trajectories in mild cognitive impairment: a data-driven approach.

ABSTRACT:

Background

Given the complex and progressive nature of mild cognitive impairment (MCI), the ability to delineate and understand the heterogeneous cognitive trajectories is crucial for developing personalized medicine and informing trial design. The primary goals of this study were to examine whether different cognitive trajectories can be identified within subjects with MCI and, if present, to characterize each trajectory in relation to changes in all major Alzheimer's disease (AD) biomarkers over time.

Methods

Individuals with a diagnosis of MCI at the first visit and ≥ 1 follow-up cognitive assessment were selected from the Alzheimer's Disease Neuroimaging Initiative database (n = 936; age 73 ± 8; 40% female; 16 ± 3 years of education; 50% APOE4 carriers). Based on the Alz

SUBMITTER: Wang X 

PROVIDER: S-EPMC10026406 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature