Impact of dysautonomic symptom burden on the quality of life in Neuromyelitis optica spectrum disorder patients.

ABSTRACT:

Background

This study aimed to investigate the clinical risk factors of dysautonomic symptom burden in neuromyelitis optica spectrum disorder (NMOSD) and its impact on patients' quality of life.

Methods

A total of 63 NMOSD patients and healthy controls were enrolled. All participants completed the Composite Autonomic Symptom Score 31 (COMPASS-31) to screen for symptoms of autonomic dysfunction. A comprehensive clinical evaluation was performed on NMOSD patients, such as disease characteristics and composite evaluations of life status, including quality of life, anxiety/depression, sleep, and fatigue. Correlated factors of dysautonomic symptoms and quality of life were analyzed.

Results

The score of COMPASS-31 in the NMOSD group was 17.2 ± 10.3, significantly higher th

SUBMITTER: Yang L 

PROVIDER: S-EPMC10026430 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature