Neoehrlichia mikurensis in Danish immunocompromised patients: a retrospective cohort study.

ABSTRACT:

Background

The tick-borne bacterium, Neoehrlichia mikurensis (N. mikurensis) can cause severe febrile illness and thromboembolic complications in immunocompromised individuals. We investigated the presence of N. mikurensis DNA in retrospectively collected plasma from a well-characterized cohort of Danish immunocompromised patients.

Methods

Plasma samples from 239 patients with immune dysfunction related to hematological or rheumatological disease or due to immunosuppressive therapy, were retrieved from a transdisciplinary biobank (PERSIMUNE) at Rigshospitalet, Copenhagen, Denmark. Serving as immunocompetent controls, plasma samples from 192 blood donors were included. All samples were collected between 2015 and 2019. Real-time PCR targeting the groEL gene was used to detect

SUBMITTER: Gynthersen RMM 

PROVIDER: S-EPMC10026440 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature