Neurological and respiratory effects of lung protective ventilation in acute brain injury patients without lung injury: brain vent, a single centre randomized interventional study.

ABSTRACT:

Introduction

Lung protective ventilation (LPV) comprising low tidal volume (VT) and high positive end-expiratory pressure (PEEP) may compromise cerebral perfusion in acute brain injury (ABI). In patients with ABI, we investigated whether LPV is associated with increased intracranial pressure (ICP) and/or deranged cerebral autoregulation (CA), brain compensatory reserve and oxygenation.

Methods

In a prospective, crossover study, 30 intubated ABI patients with normal ICP and no lung injury were randomly assigned to receive low VT [6 ml/kg/predicted (pbw)]/at either low (5 cmH₂O) or high PEEP (12 cmH₂O). Between each intervention, baseline ventilation (VT 9 ml/kg/pbw and PEEP 5 cmH₂O) were resumed. The safety limit for interruption of the interv

SUBMITTER: Beqiri E 

PROVIDER: S-EPMC10026451 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature