Radiographic airway abnormalities in untreated early rheumatoid arthritis are associated with peripheral neutrophil activation.

ABSTRACT:

Background

The role of the lung for the initiation and progression of rheumatoid arthritis (RA) is still unclear. Up to 10% of RA patients develop interstitial lung disease which remains a clinical challenge. Understanding early disease mechanisms is of great importance. The objective of this study was to determine whether there is an association between peripheral neutrophil phenotypes and presence of pulmonary abnormalities (PA) on chest high-resolution computed tomography (HRCT) in untreated early RA (ueRA).

Methods

Clinical data and blood were collected, and HRCT performed at diagnosis on 30 consecutive anti-citrullinated protein antibody (ACPA) and/or rheumatoid factor (RF) positive ueRA patients. HRCTs were evaluated for the presence of RA-associated parenchymal, airwa

SUBMITTER: Sellden T 

PROVIDER: S-EPMC10026468 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature