Association of APP gene polymorphisms and promoter methylation with essential hypertension in Guizhou: a case-control study.

ABSTRACT:

Background

Single-nucleotide polymorphisms (SNPs) and DNA methylation are crucial regulators of essential hypertension (EH). Amyloid precursor protein (APP) mutations are implicated in hypertension development. Nonetheless, studies on the association of APP gene polymorphism and promoter methylation with hypertension are limited. Therefore, this case-control aims to evaluate the genetic association of APP gene polymorphism and promoter methylation with EH in Guizhou populations.

Objective and methods

We conducted a case-control study on 343 EH patients and 335 healthy controls (including Miao, Buyi, and Han populations) in the Guizhou province of China to analyze 11 single-nucleotide polymorphisms (rs2040273, rs63750921, rs2211772, rs2830077, rs467021, rs368196, rs466433, rs

SUBMITTER: Li R 

PROVIDER: S-EPMC10026478 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature