TUBA1C: a new potential target of LncRNA EGFR-AS1 promotes gastric cancer progression.

ABSTRACT:

Background

The lack of obvious symptoms of early gastric cancer (GC) as well as the absence of sensitive and specific biomarkers results in poor clinical outcomes. Tubulin is currently emerging as important regulators of the microtubule cytoskeleton and thus have a strong potential to be implicated in a number of disorders, however, its mechanism of action in gastric cancer is still unclear. Tubulin alpha-1 C (TUBA1C) is a subtype of α-tubulin, high TUBA1C expression has been shown to be closely related to a poor prognosis in various cancers, this study, for the first time, revealed the mechanism of TUBA1C promotes malignant progression of gastric cancer in vitro and in vivo.

Methods

The expression of lncRNA EGFR-AS1 was detected in human GC cell lines by qRT-PCR. Mass spect

SUBMITTER: Wang H 

PROVIDER: S-EPMC10026485 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature