Platelet indices and blood pressure: a multivariable mendelian randomization study.

ABSTRACT:

Background

Platelet indices are blood-based parameters reflecting the activation of platelets. Previous studies have identified an association between platelet indices and blood pressure (BP). However, causal inferences are prone to bias by confounding effects and reverse causation. We performed a Mendelian randomization (MR) study to compare the causal roles between genetically determined platelet indices and BP levels.

Methods

Single-nucleotide polymorphisms (SNPs) associated with platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV), platelet distribution width (PDW), and BP at the level of genome-wide significance (p < 5 × 10^- 8) in the UK Biobank were used as instrumental variables. In bidirectional univariable MR analyses, inverse variance-wei

SUBMITTER: Xu Y 

PROVIDER: S-EPMC10026509 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature