Quantification of neuron types in the rodent hippocampal formation by data mining and numerical optimization.

ABSTRACT: Quantifying the population sizes of distinct neuron types in different anatomical regions is an essential step towards establishing a brain cell census. Although estimates exist for the total neuronal populations in different species, the number and definition of each specific neuron type are still intensively investigated. Hippocampome.org is an open-source knowledge base with morphological, physiological and molecular information for 122 neuron types in the rodent hippocampal formation. While such framework identifies all known neuron types in this system, their relative abundances remain largely unknown. This work quantitatively estimates the counts of all Hippocampome.org neuron types by literature mining and numerical optimization. We report the number of neurons in each type identifi

SUBMITTER: Attili SM 

PROVIDER: S-EPMC10026515 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature