Differential impact of obesity on the pathogenesis of RA or preclinical models is contingent on the disease status.

ABSTRACT:

Objective

Studies were performed to uncover the significance of obesity in rheumatoid arthritis (RA) and preclinical models.

Methods

Preclinical arthritis models were used to examine the impact of obesity on disease onset and remission. Conditioned media from RA adipose tissues were used to investigate the mechanism contributing to joint neutrophil influx and M1 macrophage differentiation observed in early and remission phases of arthritis.

Results

We report that mice fed with high fat diet (HFD) have an earlier onset of collagen-induced arthritis (CIA) compared with mice on regular diet. However, the differences in CIA joint swelling between the two diet groups are lost once disease is established. We found that early arthritis triggered by obesity is due to elevated

SUBMITTER: Kim SJ 

PROVIDER: S-EPMC10026536 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature