Design of a temperature-feedback controlled automated magnetic hyperthermia therapy device.

ABSTRACT:

Introduction

Magnetic hyperthermia therapy (MHT) is a minimally invasive adjuvant therapy capable of damaging tumors using magnetic nanoparticles exposed radiofrequency alternating magnetic fields. One of the challenges of MHT is thermal dose control and excessive heating in superficial tissues from off target eddy current heating.

Methods

We report the development of a control system to maintain target temperature during MHT with an automatic safety shutoff feature in adherence to FDA Design Control Guidance. A proportional-integral-derivative (PID) control algorithm was designed and implemented in NI LabVIEW^®. A standard reference material copper wire was used as the heat source to verify the controller performance in gel phantom experiments. Coupled electromagn

SUBMITTER: Sharma A 

PROVIDER: S-EPMC10026551 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature