Association Between CYP1A1 Polymorphisms and Esophageal Cancer Susceptibility: A Case-control Study.

ABSTRACT:

Background/aim

Environmental and genetic factors (such as polymorphisms) contribute to the development of esophageal cancer (EC), but the disease's molecular genetic markers are not fully understood. The purpose of this study was to investigate previously unstudied cytochrome P450 (CYP)1A1 polymorphisms (rs2606345, rs4646421 and rs4986883) in EC.

Materials and methods

We performed real-time polymerase chain reaction (qPCR) to identify CYP1A1 polymorphisms (rs2606345, rs4646421, and rs4986883) in 100 patients and 100 controls.

Results

Smoking and tandoor fumes were significantly higher in all EC and esophageal squamous cell carcinoma (ESCC) patients compared to the control group (p<0.0001). The risk of EC was two-fold higher in hot tea drinkers compared to non-drinkers

SUBMITTER: Kaya Z 

PROVIDER: S-EPMC10026655 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature