Association of PNPLA3 SNP With the Development of HBV-related Hepatocellular Carcinoma.

ABSTRACT:

Background/aim

Concomitant nonalcoholic fatty liver disease (NAFLD)/hepatic steatosis (HS) is suggested to increase the risk of hepatocellular carcinoma (HCC) in hepatitis virus B (HBV)-infected patients. Patatin-like phospholipase domain-containing 3 (PNPLA3) rs738409 gene single-nucleotide polymorphism (SNP) is well-known to be associated with the development of NAFLD/HS; however, it is still unclear whether this SNP is related to the development of HCC in HBV-infected patients.

Patients and methods

We investigated a total of 202 HBV-infected patients who received percutaneous liver biopsy, and simultaneously assessed biopsy-proven HS, insulin resistance, and the PNPLA3 SNP status. We further investigated the relationships of these factors with the development of HCC in HB

SUBMITTER: Enomoto H 

PROVIDER: S-EPMC10026664 | biostudies-literature | 2023 Mar-Apr

REPOSITORIES: biostudies-literature