A systematic review of associations between gut microbiota composition and growth failure in preterm neonates.

ABSTRACT: Growth failure is among the most prevalent and devastating consequences of prematurity. Up to half of all extremely preterm neonates struggle to grow despite modern nutrition practices. Although elegant preclinical models suggest causal roles for the gut microbiome, these insights have not yet translated into biomarkers that identify at-risk neonates or therapies that prevent or treat growth failure. This systematic review aims to identify features of the neonatal gut microbiota that are positively or negatively associated with early postnatal growth. We identified 860 articles, of which 14 were eligible for inclusion. No two studies used the same definitions of growth, ages at stool collection, and statistical methods linking microbiota to metadata. In all, 58 different taxa were associat

SUBMITTER: Neves LL 

PROVIDER: S-EPMC10026866 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature