GPR120 promotes neutrophil control of intestinal bacterial infection.

ABSTRACT: G-protein coupled receptor 120 (GPR 120) has been implicated in anti-inflammatory functions. However, how GPR120 regulates the neutrophil function remains unknown. This study investigated the role of GPR120 in the regulation of neutrophil function against enteric bacteria. 16S rRNA sequencing was used for measuring the gut microbiota of wild-type (WT) mice and Gpr120^-/- mice. Citrobacter rodentium infection and dextran sulfate sodium (DSS)-induced colitis models were performed in WT and Gpr120^-/- mice. Mouse peritoneal-derived primary neutrophils were used to determine the neutrophil functions. Gpr120^-/- mice showed altered microbiota composition. Gpr120^-/- mice exhibited less capacity to clear intestinal Cit

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC10026904 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature