Human pancreatic capillaries and nerve fibers persist in type 1 diabetes despite beta cell loss.

ABSTRACT: The autonomic nervous system regulates pancreatic function. Islet capillaries are essential for the extension of axonal projections into islets, and both of these structures are important for appropriate islet hormone secretion. Because beta cells provide important paracrine cues for islet glucagon secretion and neurovascular development, we postulated that beta cell loss in type 1 diabetes (T1D) would lead to a decline in intraislet capillaries and reduction of islet innervation, possibly contributing to abnormal glucagon secretion. To define morphological characteristics of capillaries and nerve fibers in islets and acinar tissue compartments, we analyzed neurovascular assembly across the largest cohort of T1D and normal individuals studied thus far. Because innervation has been studied

SUBMITTER: Richardson TM 

PROVIDER: S-EPMC10027091 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature