Cnih3 Deletion Dysregulates Dorsal Hippocampal Transcription across the Estrous Cycle.

ABSTRACT: In females, the hippocampus, a critical brain region for coordination of learning, memory, and behavior, displays altered physiology and behavioral output across the estrous or menstrual cycle. However, the molecular effectors and cell types underlying these observed cyclic changes have only been partially characterized to date. Recently, profiling of mice null for the AMPA receptor trafficking gene Cnih3 have demonstrated estrous-dependent phenotypes in dorsal hippocampal synaptic plasticity, composition, and learning/memory. We therefore profiled dorsal hippocampal transcriptomes from female mice in each estrous cycle stage, and contrasted it with that of males, across wild-type (WT) and Cnih3 mutants. In wild types, we identified only subtle differences in gene expression

SUBMITTER: Mulvey B 

PROVIDER: S-EPMC10027183 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature