Differential effects of emotional valence on mnemonic performance with greater hippocampal maturity.

ABSTRACT: The hippocampal formation (HF) facilitates declarative memory, with subfields providing unique contributions to memory performance. Maturational differences across subfields facilitate a shift toward increased memory specificity, with peripuberty sitting at the inflection point. Peripuberty is also a sensitive period in the development of anxiety disorders. We believe HF development during puberty is critical to negative overgeneralization, a common feature of anxiety disorders. To investigate this claim, we examined the relationship between mnemonic generalization and a cross-sectional pubertal maturity index (PMI) derived from partial least squares correlation (PLSC) analyses of subfield volumes and structural connectivity from T1-weighted and diffusion-weighted scans, respectively. Part

SUBMITTER: Kimbler A 

PROVIDER: S-EPMC10027236 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature