Non-Alcoholic Steatohepatitis Severity Associates with FGF21 Level and Kidney Glucose Uptake.

ABSTRACT: Background: Nonalcoholic steatohepatitis (NASH) is a severe form of fatty liver disease that has been shown to be associated with chronic kidney disease (CKD). Mechanism for the association of NASH with CKD remains unclear. In this study, we examined the association between NASH severity and kidney glucose uptake and the liver-secreted signaling molecule fibroblast growth factor 21 (FGF21). Methods: Kinetic parameters for kidney glucose transport rate (K₁) and standardized uptake value (SUV) were determined using dynamic positron emission tomography after injection of ¹⁸F-fluorodeoxyglucose. Liver biopsies were scored for NASH activity (inflammation and ballooning), fibrosis, and steatosis FGF21 was measured from fasting serum samples. Pati

SUBMITTER: Sarkar S 

PROVIDER: S-EPMC10027339 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature