Divergent transcriptional regulation of astrocyte reactivity across disorders.

ABSTRACT: Astrocytes respond to injury and disease in the central nervous system with reactive changes that influence the outcome of the disorder^1-4. These changes include differentially expressed genes (DEGs) whose contextual diversity and regulation are poorly understood. Here we combined biological and informatic analyses, including RNA sequencing, protein detection, assay for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq) and conditional gene deletion, to predict transcriptional regulators that differentially control more than 12,000 DEGs that are potentially associated with astrocyte reactivity across diverse central nervous system disorders in mice and humans. DEGs associated with astrocyte reactivity exhibited pronounced heterogeneity across disorders.

SUBMITTER: Burda JE 

PROVIDER: S-EPMC10027402 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature