ScAnnotate: an automated cell-type annotation tool for single-cell RNA-sequencing data

ABSTRACT: Abstract

Motivation

Single-cell RNA-sequencing (scRNA-seq) technology enables researchers to investigate a genome at the cellular level with unprecedented resolution. An organism consists of a heterogeneous collection of cell types, each of which plays a distinct role in various biological processes. Hence, the first step of scRNA-seq data analysis is often to distinguish cell types so they can be investigated separately. Researchers have recently developed several automated cell-type annotation tools, requiring neither biological knowledge nor subjective human decisions. Dropout is a crucial characteristic of scRNA-seq data widely used in differential expression analysis. However, no current cell annotation method explicitly utilizes dropout information. Fully utilizing dropout i

SUBMITTER:  

PROVIDER: S-EPMC10027414 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature