A fast linkage method for population GWAS cohorts with related individuals.

ABSTRACT: Linkage analysis, a class of methods for detecting co-segregation of genomic segments and traits in families, was used to map disease-causing genes for decades before genotyping arrays and dense SNP genotyping enabled genome-wide association studies in population samples. Population samples often contain related individuals, but the segregation of alleles within families is rarely used because traditional linkage methods are computationally inefficient for larger datasets. Here, we describe Population Linkage, a novel application of Haseman-Elston regression as a method of moments estimator of variance components and their standard errors. We achieve additional computational efficiency by using modern methods for detection of IBD segments and variance component estimation, efficient prepro

SUBMITTER: Zajac GJM 

PROVIDER: S-EPMC10027464 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature