Lens Free Holographic Imaging for Urinary Tract Infection Screening.

ABSTRACT:

Objective

The diagnosis of urinary tract infection (UTI) currently requires precise specimen collection, handling infectious human waste, controlled urine storage, and timely transportation to modern laboratory equipment for analysis. Here we investigate holographic lens free imaging (LFI) to show its promise for enabling automatic urine analysis at the patient bedside.

Methods

We introduce an LFI system capable of resolving important urine clinical biomarkers such as red blood cells, white blood cells, crystals, and casts in 2 mm thick urine phantoms.

Results

This approach is sensitive to the particulate concentrations relevant for detecting several clinical urine abnormalities such as hematuria and pyuria, linearly correlating to ground truth hemacytometer measureme

SUBMITTER: McKay GN 

PROVIDER: S-EPMC10027617 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature