[¹⁸F]RO948 tau positron emission tomography in genetic and sporadic frontotemporal dementia syndromes.

ABSTRACT:

Purpose

To examine [¹⁸F]RO948 retention in FTD, sampling the underlying protein pathology heterogeneity.

Methods

A total of 61 individuals with FTD (n = 35), matched cases of AD (n = 13) and Aβ-negative cognitively unimpaired individuals (n = 13) underwent [¹⁸F]RO948PET and MRI. FTD included 21 behavioral variant FTD (bvFTD) cases, 11 symptomatic C9orf72 mutation carriers, one patient with non-genetic bvFTD-ALS, one individual with bvFTD due to a GRN mutation, and one due to a MAPT mutation (R406W). Tracer retention was examined using a region-of-interest and voxel-wise approaches. Two individuals (bvFTD due to C9orf72) underwent postmortem neuropathological examination. Tracer binding was additionally assessed in vitro using [³H]RO948 autora

SUBMITTER: Santillo AF 

PROVIDER: S-EPMC10027632 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature